Paramedic National Registry Practice

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What is typically the first sign of anaphylaxis?

Skin reactions
Respiratory distress
Gastrointestinal symptoms
Cardiovascular collapse

The correct answer is: Skin reactions

The first sign of anaphylaxis is typically skin reactions, which may include hives, flushing, swelling, or other skin manifestations. These reactions occur due to the rapid release of histamine and other mediators from mast cells following exposure to an allergen. The initial response can be quite pronounced, leading individuals to notice changes in their skin before other symptoms develop. While respiratory distress, gastrointestinal symptoms, and cardiovascular issues can also occur as the condition progresses, they usually arise after the initial skin reactions have taken place. Early recognition of skin signs can be crucial for initiating prompt treatment, as it allows for timely intervention that can help prevent more severe symptoms and potential complications associated with anaphylaxis.